the effects of piper sarmentosum water extract on the expression and activity of 11β-hydroxysteroid dehydrogenase type 1 in the bones with excessive glucocorticoids

نویسندگان

farihah hj suhaimi department of anatomy, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia

elvy suhana mohd ramli department of anatomy, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia

ima nirwana soelaiman department of pharmacology, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia

faizah othman department of anatomy, universiti kebangsaan malaysia, kuala lumpur, wp, malaysia

چکیده

background: long-term glucocorticoid therapy causes secondary osteoporosis leading to pathological fractures. glucocorticoid action in bone is dependant upon the activity of 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-hsd1). piper sarmentosum is a local herb that possesses the ability to inhibit 11-βhsd1 enzyme activity. we aimed to determine the effects of piper sarmentosum water extract on 11-βhsd1 expressions and activity in the bones of glucocorti-coid-treated adrenalectomized rats. methods: forty male sprague–dawley rats (200-250 g) were used. twenty-four animals were adrenalectomized and received intramuscular injection of dexamethasone (120 μg/kg/day). they were simultaneously administered with either piper sarmentosum water extract (125 mg/kg/day), gca (120 mg/kg/day) or distilled water as vehicle by oral gavage for two months. eight animals were sham-operated and given vehicle daily, i.e. intramuscular olive oil and oral distilled water. results: following two months treatment, dexamethasone-treated adrenalectomized rats had significantly lower 11β-hsd1 dehydrogenase activity and higher 11β-hsd1 expression in the femoral bones compared to the sham-operated and baseline group. the rats supplemented with piper sarmentosum water extract had significantly higher 11β-hsd1 dehydrogenase activity and lower 11β-hsd1 expression in the bones. conclusion: the results showed that piper sarmentosum water extract had the ability to prevent glucocorcoticoid excess in the bones of glucocorticoid-treated adrenalectomized rats through the local modulation of 11β-hsd1 expression and activity, and may be used as prophylaxis for osteoporosis in patients on long-term glucocorticoid treatment.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids

Background: Long-term glucocorticoid therapy causes secondary osteoporosis leading to pathological fractures. Glucocorticoid action in bone is dependant upon the activity of 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1). Piper sarmentosum is a local herb that possesses the ability to inhibit 11-βHSD1 enzyme activity. We aimed to determine the effects of Piper sarmentosum wat...

متن کامل

The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids

BACKGROUND Long-term glucocorticoid therapy causes secondary osteoporosis leading to pathological fractures. Glucocorticoid action in bone is dependant upon the activity of 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1). Piper sarmentosum is a local herb that possesses the ability to inhibit 11-βHSD1 enzyme activity. We aimed to determine the effects of Piper sarmentosum water extrac...

متن کامل

the effects of changing roughness on the flow structure in the bends

flow in natural river bends is a complex and turbulent phenomenon which affects the scour and sedimentations and causes an irregular bed topography on the bed. for the reason, the flow hydralics and the parameters which affect the flow to be studied and understand. in this study the effect of bed and wall roughness using the software fluent discussed in a sharp 90-degree flume bend with 40.3cm ...

the analysis of the role of the speech acts theory in translating and dubbing hollywood films

از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...

15 صفحه اول

the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)

cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of medical sciences

جلد ۳۷، شماره ۱، صفحات ۳۹-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023